Fog Harbor Fish House at Pier 39. It might have been early (5:15 pm) but since we were still on east coast time, it was a late dinner, even for us. And we were really hungry.
We'd go back on our next trip to San Francisco. It was in a good location for us, wheelchair accessible, there was room to maneuver between tables, service was wonderful, everyone was friendly and helpful, a great view, and yummy food. Some might argue pricey, but it's in a tourist area, on the water, great views, and there's lots of seafood.